Plants are well known to contain a variety of polyphenols with electrophilic functional groups.
These phytochemicals can covalently modify nucleophilic cysteine residues that change the target protein confirmation, alter protein function and modulate biological action.
In this paper we describe different proteomic strategies that have been employed to study these natural product-protein interactions.
The title of the article is “Covalent Modification of Proteins by Plant-Derived Natural Products: Proteomic Approaches and Biological Impacts” https://pubmed.ncbi.nlm.nih.gov/32949481/