Rosemary is rich in phytochemicals called diterpenes and are being studied for their possible health benefits.
In a paper we published in the journal of Carcinogenesis we describe how carnosic acid can target androgen receptor in prostate cancer cells.
If you are looking for natural ways to lower inflammation click here.
In this study we provide evidence that carnosic acid directly binds the ligand binding domain.
We followed this up with additional experiments using prostate cancer cells and an animal model.
Congratulations to Sakina for getting this paper accepted into Carcinogenesis!
You can read more about our project here.
Here is part of the abstract to our paper:
Androgen deprivation therapy in prostate cancer is extremely effective; however, due to the continuous expression and/or mutagenesis of androgen receptor (AR), the resistance to antihormonal therapy is a natural progression. Consequently, targeting the AR for degradation offers an alternate approach to overcome this resistance in prostate cancer….…Degradation of AR and induction of CHOP protein were also evident in vivo along with a 53% reduction in growth of xenograft prostate cancer tumors. In addition, carnosic acid-induced ER stress in prostate cancer cells but not in normal prostate epithelial cells procured from patient biopsies. In conclusion, these data suggest that molecules such as carnosic acid could be further evaluated and optimized as a potential therapeutic alternative to target AR in prostate cancer.
Reference:
Sakina M Petiwala, Gongbo Li, Maarten C Bosland, Daniel D Lantvit, Pavel A Petukhov, Jeremy J Johnson. Carnosic acid promotes degradation of the androgen receptor and is regulated by the unfolded protein response pathway in vitro and in vivo. Carcinogenesis. 2016 Aug; 37(8):827-838.
