Can phytochemicals from mangosteen fruit improve gastrointestinal health – new paper

by Dr. Jeremy Johnson | Posted on

We recently published a paper describing how the mangosteen fruit (Garcinia mangostana) has anti-inflammatory and anti-oxidative properties in HT-29 cells. 

For this project we isolated out individual xanthones from the mangosteen fruit to understand how AHR (Aryl Hydrocarbon Receptor) and Nrf2 can be induced using a luciferase based experiment. 

The results of our study suggest a possible dual action of AHR and Nrf2 activation by selected xanthones isolated from the mangosteen fruit.

This paper was published in Free Radical Biology and Medicine and is titled, “Prenylated xanthones from mangosteen (Garcinia mangostana) activate the AhR and Nrf2 pathways and protect intestinal barrier integrity in HT-29 cells.

You can access the article here: https://pubmed.ncbi.nlm.nih.gov/33310139/

About the author

Dr. Johnson received his PharmD and PhD at the University of Wisconsin where he also completed a clinical research fellowship evaluating phytochemicals and botanical extracts. He is an associate professor and licensed pharmacist he offers a unique perspective on the most current scientific literature related to the health and nutrition. His research program is active and has led to more than 50 publications and published abstracts related to the health promoting properties of natural products, phytochemicals and plant extracts. He has presented some of his research findings at international scientific meetings in the US, Italy, Austria, Israel, France, China, Philippines and Turkey.

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